En 1893, Maria Montessori est la première femme diplômée de la faculté de médecine de Rome. Malgré la misogynie de l'époque, elle parvient, grâce au professeur Giuseppe Montessano, à se spécialiser en psychiatrie infantile, car Maria s'intéresse au sort des enfants abandonnés et recueillis dans les asiles. Elle entreprend de sauver ceux qui sont aptes à étudier. Maria propose alors une alternative pour les soigner : la pédagogie.

Ernesto and Filippo, two high school teachers, couldn’t be more different: Filippo is a cheerful liberal who is constantly online. Handsome and youthful, he is a serial seducer on the social networks. Ernesto, instead is a stern conservative, rigorously computerless. He is probably the last person around who still has a first-generation cell phone and his teaching methods are very traditional. They used to be best friends but an unresolved fight kept them far apart, until the day fate intervened and they found themselves teaching at the same school. Their opposite viewpoints will soon and inevitably lead to a new clash. The internet will force them to deal with their past, which resurfaces in the shape of Nina, a young woman who conducts an experiment on them: Filippo must try to leave the world of Internet and Ernesto must try to enter it.

Simone, a clumsy financier, falls in love with Claudia, who’s living on her grandma’s retirement checks. When the old lady dies Claudia hides the body in a freezer, and sets up a fraud with the help of some friends to avoid bankruptcy.