Indiana Jones se lance cette fois‐ci à la recherche du Saint Graal, accompagné de l’éminent et très maladroit Dr Henry Jones, son père. Malheureusement, ils ne sont pas les seuls lancés sur la trace du trésor, les nazis le convoitent également.

Horror novelist Luke Sinclair retreats to a small town to finish writing his latest book. A young woman is murdered in the woods nearby, in circumstances similar to those in his bestselling novel, "Reaper". Faced with increasing pressure from a suspicious local sheriff, as well as the advances of a female FBI investigator, he must uncover the killer before he or she strikes again, further implicating him in the crime.